{"id":21390,"date":"2024-07-07T20:50:08","date_gmt":"2024-07-07T18:50:08","guid":{"rendered":"https:\/\/www.pmfst.unist.hr\/znanost\/?p=21390"},"modified":"2024-12-06T13:50:48","modified_gmt":"2024-12-06T12:50:48","slug":"grupa-za-identifikaciju-i-dizajn-te-karakterizaciju-i-primjenu-antimikrobnih-peptide","status":"publish","type":"post","link":"https:\/\/www.pmfst.unist.hr\/znanost\/grupa-za-identifikaciju-i-dizajn-te-karakterizaciju-i-primjenu-antimikrobnih-peptide\/","title":{"rendered":"Znanstveno-istra\u017eiva\u010dka grupa za identifikaciju i dizajn, te karakterizaciju i primjenu antimikrobnih peptide"},"content":{"rendered":"
[vc_row][vc_column width=”1\/4″][mk_title_box color=”#1e73be” margin_bottom=”0″ font_family=”none”]Voditelj grupe<\/b>[\/mk_title_box][mk_employees style=”boxed” column=”1″ employees=”19573″][\/vc_column][vc_column width=”3\/4″][mk_title_box color=”#1e73be” margin_bottom=”0″ font_family=”none”]\u010clanovi grupe<\/b>[\/mk_title_box][mk_custom_box padding_vertical=”10″][mk_custom_list style=”mk-moon-user-3″]\n
    \n
  • \u00a0 \u00a0prof. dr. sc. Damir Vuki\u010devi\u0107 (PMF Split)<\/span><\/li>\n
  • \u00a0 \u00a0izv. prof. dr. sc. Larisa Zorani\u0107 (PMF Split)<\/span><\/li>\n
  • \u00a0 \u00a0doc. dr. sc. Lucija Krce (PMF Split)<\/span><\/li>\n
  • \u00a0 \u00a0doc. dr. sc. Ivica \u0160amani\u0107 (PMF Split)<\/span><\/li>\n
  • \u00a0 \u00a0prof. dr. sc. Alessandro Tossi (Sveu\u010dili\u0161te u Trstu, Trst, Italija)<\/span><\/li>\n
  • \u00a0 \u00a0izv. prof. dr. sc. Marco Gerdol (Sveu\u010dili\u0161te u Trstu, Trst, Italija)<\/span><\/li>\n
  • \u00a0 \u00a0dr. sc. Andrea Caporale (CNR, Basovizza, Italija)<\/span><\/li>\n
  • \u00a0 \u00a0prof. dr. sc. Ivona Mladineo (Biolo\u0161ki centar \u010ce\u0161ke akademije znanosti, \u010ce\u0161ke Budejovice, \u010ce\u0161ka)<\/span><\/li>\n<\/ul>\n[\/mk_custom_list][\/mk_custom_box][\/vc_column][\/vc_row][vc_row][vc_column][mk_title_box color=”#1e73be” font_family=”none”]Odjel\/Katedra: <\/strong><\/p>\n

    Odjel za biologiju[\/mk_title_box][vc_column_text css=”.vc_custom_1520591712979{margin-bottom: 0px !important;}”]\n

    Opis istra\u017eivanja:<\/strong><\/h4>\n

    U radu grupe sudjeluje interdisciplinarni tim znanstvenika s ciljem identifikacije\/dizajna antimikrobnih peptida (AMP-a) koji pokazuju aktivnost naspram gram-pozitivnih i\/ili gram-negativnih bakterija dok istovremeno nisu toksi\u010dni ili su blago toksi\u010dni naspram stanica doma\u0107ina. Poseban fokus je stavljen na odre\u0111ivanje mehanizma djelovanja AMP-a, odnosno na SAR studije (engl. structure activity relationship<\/em>) prilikom \u010dega se uspore\u0111uje primarna i sekundarna struktura peptida s aktivnosti naspram bakterija i mehanizmom djelovanja. U tu svrhu promatraju se interakcije peptida s bakterijskom membranom, te utjecaj na unutarstani\u010dne komponente bakterija, npr. na ribosome i nukleinske kiseline. Daljnja mehanisti\u010dka opa\u017eanja, koja zaobilaze eksperimentalna ograni\u010denja, pribavljaju se putem simulacija molekulske dinamike. Dugoro\u010dni cilj grupe je razviti nove u\u010dinkovite lijekove, te se peptidi koji najvi\u0161e obe\u0107avaju na osnovi in vitro<\/em> testiranja, razmatraju kroz potencijalnu biotehnolo\u0161ku i biomedicinsku primjenu.<\/p>\n[\/vc_column_text][vc_column_text css=”.vc_custom_1520591959083{margin-bottom: 0px !important;}”]\n

    Partnerski potencijali:<\/strong><\/h4>\n

    Odjel za \u017eivotne znanosti, Sveu\u010dili\u0161te u Trstu, Trst, Italija; Institut za kristalografiju, CNR, Basovizza, Italija; Institut za parazitologiju, Biolo\u0161ki centar \u010ce\u0161ke akademije znanosti, \u010ce\u0161ke Budejovice, \u010ce\u0161ka<\/p>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1520603890149{margin-bottom: 0px !important;}”]\n

    Financijski i drugi potencijali:<\/strong><\/h4>\n

    Institucijski znanstveni projekt<\/p>\n[\/vc_column_text][vc_column_text css=”.vc_custom_1726614022464{margin-bottom: 0px !important;}”]Znanstveni ciljevi<\/strong> kojima se daje doprinos: Z-1, Z-3, Z-4, Z-7, Z-9, Z-10, G-1<\/p>\n

    Mjerljivi pokazatelji<\/strong> kojima se daje doprinos i vrijednost doprinosa: -Z-04: min. 50%, R-Z-03: 4, R-Z-07: 3, R-Z-F3: 4x Q1 rada, R-Z-F7: 1, R-Z-F8: 1, R-G-01: 1[\/vc_column_text][\/vc_column][\/vc_row][vc_column][\/vc_column]\n<\/div>","protected":false},"excerpt":{"rendered":"

    [vc_row][vc_column width=”1\/4″][mk_title_box color=”#1e73be” margin_bottom=”0″ font_family=”none”]Voditelj grupe[\/mk_title_box][mk_employees style=”boxed” column=”1″ employees=”19573″][\/vc_column][vc_column width=”3\/4″][mk_title_box color=”#1e73be” margin_bottom=”0″ font_family=”none”]\u010clanovi grupe[\/mk_title_box][mk_custom_box padding_vertical=”10″][mk_custom_list style=”mk-moon-user-3″] \u00a0 \u00a0prof. dr. sc. Damir Vuki\u010devi\u0107 (PMF Split) \u00a0 \u00a0izv. prof. dr. sc. Larisa Zorani\u0107 (PMF Split) \u00a0 \u00a0doc. dr. sc. Lucija Krce (PMF Split) \u00a0 \u00a0doc. dr. sc. Ivica \u0160amani\u0107 (PMF Split) \u00a0 \u00a0prof. dr. sc. Alessandro Tossi […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[154,149],"tags":[],"poredak":[],"class_list":["post-21390","post","type-post","status-publish","format-standard","hentry","category-istrazivacke-grupe-odjela-za-biologiju","category-nove-istrazivacke-grupe"],"acf":[],"yoast_head":"\nZnanstveno-istra\u017eiva\u010dka grupa za identifikaciju i dizajn, te karakterizaciju i primjenu antimikrobnih peptide - Znanstvena djelatnost, PMF Split<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Znanstveno-istra\u017eiva\u010dka grupa za identifikaciju i dizajn, te karakterizaciju i primjenu antimikrobnih peptide - Znanstvena djelatnost, PMF Split\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=”1\/4″][mk_title_box color=”#1e73be” margin_bottom=”0″ font_family=”none”]Voditelj grupe[\/mk_title_box][mk_employees style=”boxed” column=”1″ employees=”19573″][\/vc_column][vc_column width=”3\/4″][mk_title_box color=”#1e73be” margin_bottom=”0″ font_family=”none”]\u010clanovi grupe[\/mk_title_box][mk_custom_box padding_vertical=”10″][mk_custom_list style=”mk-moon-user-3″] \u00a0 \u00a0prof. dr. sc. Damir Vuki\u010devi\u0107 (PMF Split) \u00a0 \u00a0izv. prof. dr. sc. Larisa Zorani\u0107 (PMF Split) \u00a0 \u00a0doc. dr. sc. Lucija Krce (PMF Split) \u00a0 \u00a0doc. dr. sc. Ivica \u0160amani\u0107 (PMF Split) \u00a0 \u00a0prof. dr. sc. 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