Dragi svi,
zadovoljstvo nam je pozvati vas na 81. Fakultetski seminar 4. 12. 2025. u A1-1 u 11:00 na temu:
Multicomponent crystals: preparation and structural characterization
koji će održati dr. Artur Mirocki s Faculty of Chemistry, University of Gdańsk.
Sažetak
Dr. Mirocki will present recent advances in the design and characterization of multicomponent crystals containing active pharmaceutical ingredients (APIs). After a brief introduction to crystal engineering in the context of drug development, the lecture will focus on strategies for constructing multicomponent systems—such as cocrystals and drug–drug crystals, based on non-steroidal anti-inflammatory drugs, antibiotics, anticancer agents, and related compounds. Particular emphasis will be placed on mechanochemical and solution-based methods for obtaining these materials, illustrated with case studies involving acridines and their derivatives. Dr. Mirocki will discuss how structural analysis techniques are used to elucidate molecular packing and intermolecular interactions, and how these features translate into modified physicochemical and pharmaceutical properties of the resulting crystals. The lecture will also address current challenges in the rational design of multicomponent drug crystals, as well as perspectives for future research and collaboration with the Laboratory of Crystallochemistry at the University of Gdańsk.
Kratki životopis
Dr. Artur Mirocki is an Assistant Professor at the Faculty of Chemistry, University of Gdańsk. He completed his Bachelor’s degree in 2016 at the University of Warsaw, followed by a Master’s degree in 2018 at the University of Gdańsk, where he also obtained his PhD in Chemical Sciences in 2023. His research focuses on the crystal engineering of multicomponent crystals containing active pharmaceutical ingredients (APIs), including non-steroidal anti-inflammatory drugs, antibiotics, and anticancer compounds. In particular, he investigates how different crystallization strategies and molecular arrangements influence the physicochemical and pharmaceutical properties of drug-related solids. Dr. Mirocki has served as principal investigator of the project funded by the National Science Center (Poland) entitled “Two approaches: mechanochemistry vs. solution crystallization to obtain multicomponent drug-drug crystals with ethacridine”, which explores complementary synthetic routes to design and obtain novel multicomponent drug–drug crystal forms.