Zadovoljstvo nam je pozvati vas na 85. Fakultetski seminar 23. 6. 2026. u B3-48 u 11:00 na temu:
Nanostructures as brain cell modulators
koji će održati prof. dr. sc. Dušica Maysinger sa Sveučilišta McGill u Montrealu, Kanada.
Sažetak
Liganded gold nanoclusters (AuNC) are nanostructures in the non-scalable regime where every atom matters for the properties. In recent years, these nanoclusters have been used for their unique physicochemical properties for diagnostic and therapeutic applications in biomedicine. They are used instead of organic dyes as fluorescent markers in bioimaging and biolabeling. One of the challenges in their application is understanding how these nanostructures interact within a complex cellular environment, for example, within microglia. Microglia are specialized immune cells in the brain that patrol the brain and remove damaged neurons and pathogens. In our joint research (McGill-Lyon-PMFST) we focus on exactly this question, and we investigate the cytotoxicity and effects of clusters of different sizes (e.g., Au10, Au25, Au102) protected with different ligands (e.g., glutathione or cysteine) on the alarmin proteins in human microglia.
Kratki životopis
Professor Emerita, active, at McGill University, is a renowned expert in nanostructures and brain cells with a rich international career, integrating nanomedicine with neuroscience. She has over 37 000 citations and an H index of 66. She got her PhD in USA, University of Southern California as a Fullbright fellow and research assistant. She did several post-doctoral trainings in Europe: Max Planck Insitute in Martinsried as an Alexander von Humboldt fellow, Cell biology in Heidelberg, Microdialysis in Stockholm, Neuroscience in Oxford (UK) and at McGill, Montreal where she progressed from this status to full professor, and now being Professor Emerita. Her expertise are gold and polymeric nanostructures, nanomedicine, nano sensors, organelles imaging and functions, biochemical and functional assays.
